FGF  Receptor  Tyrosine  Kinase  Autoinhibition

FGFR autoinhibition. (A) Schematic representation of our proposed model for FGFR autoinhibition. (B) Sequence alignment of D1, the D1-D2 linker and D2 of FGFRs. The AB in the D1-D2 linker is highlighted in red. The domain boundaries of D1 and D2 are indicated by boxes. The secondary structure elements of D2 are indicated. The location of Kallmann syndrome mutations are indicated by asterisks.