Principles
in Structural Biology
The goals of this course are
to provide students with an introduction to protein structure and to demonstrate
how knowledge of the three-dimensional structures of proteins affords an
in-depth understanding of biological processes. A primer on structure determination
by x-ray crystallography, electron microscopy, and NMR spectroscopy will
also be given.
4 credit hours - Fall semester
2 lectures and 1 discussion
session per week
Text: "Introduction to
Protein Structure" by Branden and Tooze.
Suitable for 1st and 2nd
year students
Course Director
Stevan Hubbard
Course Website
Topics
Principles of protein structure
and folding
Basic techniques in x-ray
crystallography
Basic techniques in electron
microscopy
Enzyme structure and mechanism
Molecular machines
Membrane proteins
Protein-nucleic acid recognition
Ligand-receptor recognition
Protein-protein interactions
in signal transduction
Computational approaches
to molecular modeling
Protein structure determination
by NMR spectroscopy
Analysis of proteins by mass
spectrometry
Instructors
Joel Belasco
Stevan Hubbard
Neville Kallenbach
Xiangpeng Kong
Alexej Jerschow
Moosa Mohammadi
Thomas Neubert
David Ron
David Stokes
Da-Neng Wang
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