Welcome to the New York University School of Medicine Image Core Facility!

The image core facility features a wide spectrum of microscopy equipment with technical assistance both in sample preparation and image acquisition. The core facility is housed on the 2nd floor of the Skirball Institute of Biomolecular Medicine and consists of two parts: the Electron Microscopy and Light Microscopy.

Light Microcopy
Established in March 1, 2009, Light microscopy core provides comprehensive imaging systems dedicated to bringing state of the art methods in modern light microscopy. These include Zeiss Axioplan Wide-field fluorescence/DIC upright microscope, Zeiss LSM 510 laser scanning confocal/Confocor2, Zeiss LSM710 laser scanning confocal with multiphoton capability, Leica TCS SP5 confocal and Applied Precision PersonalDV live cell imaging system. Under supervision by Dr. Michael Dustin, and assistance by highly experienced technical stuff, we hope to provide researchers with broad array of the best services.

Electron Microcopy
The Electron microscopy core was started on October 1st , 2005. The Lab is equipped with two Philips Transmission Electron Microscopes, a CM12 and a CM200/FEG. Additionally, we have a new BOC Edward Auto 306 Evaporator, a microdesitometer with an optical diffraction bench, a new Leica EM UC6/EM FC6 cryo-ultramicrotome and other EM-related devices and tools. The highly educated and experienced electron microscopy staff will provide the instruction, consultation, assistance, and collaboration for any research involving electron microscopy. Our current services include sample preparation, ultramicrotomy, immunolabeling, and morphological analysis by transmission electron microscopy. Special techniques are also available including negative staining, rotary shadowing of the macromolecules, and cryoultramicrotomy. Trained and experienced users are permitted to use the facility following a fee-per-service basis (image core facility- Pricing).

If you are interested in analysis your tissue at ultrastructure level, please contact with the facility director for the further information:

Alice Liang, Ph.D.
Skirball Institute of Biomolecular Medicine
NYU School of Medicine
540 First Avenue, 2nd Floor, EM Suite
New York, NY 10016
Tel: (212) 263-7644 (office); (212) 263-7099 (lab)
Fax: (212) 263-7643
fengxia.liang@med.nyu.edu


EM Gold-labeling of Vasa protein in early Drosophila embryos. In Drosophila, Vasa protein is localized to polar granules, organelles found only in germ plasm of early cleavage embryos. Vasa protein is required for polar granule assembly as well as for germ cell formation. The picture was captured with Gatan digital camera of CM-12 transmission electron microscope. Alice Liang, in collaboration with Ruth Lehmann (NYU School of Medicine).