Since its establishment in 2005, the New York University Protein MassSpectrometry Core Facility for neuroscience has provided cutting edgemass spectrometry-based protein analysis to molecular neuroscientistsat the New York University School of Medicine. Funding from NIH-NINDS has enabled neuroscientists at NYU to take advantage of sophisticatedand involved protein mass spectrometry and proteomics that wouldotherwise not be available to them, and guarantee them access to thetechnology. Neuroscientists at New York University can identify fromone to thousands of proteins of interest, of these proteins such asphosphorylation, glycosylation, proteolysis and modification by lipids,perform functional proteomics studies to identify the proteins involvedin key signal transduction processes in neurons, and characterizeprotein-protein interactions by surface plasmon resonance.

SILAC in Primary Neurons