Recent Publications

Rosenbluth, J., Schiff, R., Lam, P., Nuriel, T. and Chao, M.V. (2009) Spongiform pathology in mouse CNS lacking ‘neuropathy target esterase’ and cellular prion protein. Neurobiol Disease, ahead of print.

Read, D.J., Li, Y., Chao, M.V., Cavanagh, J.B. and Glynn, P. (2009) Neuropathy target esterase is required adult vertebrate axon maintenance. J Neuroscience, in press.

Huang, S.H., Zhao, L., Sun, Z.P., Li, X.Z., Geng, Z., Zhang, K.D., Chao, M.V. and Chen, Z.Y. (2009) Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1. J. Biol. Chem. 284, 15126-15136.

Nagahara, A.H., Merrill, D.A., Coppola, G., Tsukada, S., Schroeder, B.E., Shaked, G.M., Wang, L., Blesch, A., Kim, A., Conner, J.M., Rockenstein, E., Chao, M.V., Koo, E.H., Geschwind, D., Masliah, E., Chiba, A.A. and Tuszynski, M.H. (2009) Nature Med. 15, 331-337.

Wu, S.H., Arevalo, J.C., Sarti, F., Tessarollo, L, Gan. W.B. and Chao, M.V. (2009) Ankryin repeat rich membrane spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo. Dev Neurobiology 69, 547-557.

Bath, K.G., Mandairon, N., Jing, D., Rajagopal, R., Kapoor, R., Chen, Z-Y., Khan, T, Proenca, C.C., Kraemer, R., Cleland, T.A., Hempstead, B.L., Chao, M.V. and Lee, F.S. (2008) Variant Brain-derived Neurotrophic Factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. J. Neuroscience 28, 2383-2393.

Sniderhan, L.F., Stout, A., Lu, Y., Chao, M.V. and Maggiwar, S.B. (2008) Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signaling. Mol. Cell. Neurosci. 38, 404-416.

Spellman, D.S., Deinhardt, Darie, C.C., Chao, M.V. and Neurbert, T.A. (2008) Stable isotopic labeling by amino acids in cultured primary neurons: application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signaling. Mol Cell Proteomics 7, 1067-1076.

Iwakawa, Y., Nawa, H., Sora, I. and Chao, M.V. (2008) Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons. J. Biol. Chem 283, 15799-15806.

Jeanneteau, F., Garabedian, M. and Chao, M.V. (2008) Activation of Trk neurotrophin receptors
by glucocorticoids provides a neuroprotective effect. Proc. Natl. Acad. Sci. 105, 4862-4867.

Wiese, S., Jablonka, S., Holtmann, B., Orel, N., Rajagopal, R., Chao, M.V. and Sendtner, M.
(2007) Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. Proc. Natl. Acad. Sci. 104, 17210-17215.

Sachs, B.D., Baillie, G.S., McCall, J.R., Passino. M.A., Schachtrup, C.,, Wallace, D.A., Dunlop,
A.J., MacKenzie, K.F., Klussmann, E., Lynch, M.J., Sikorski, S.L., Nuriel, T., Tsigelny, I., Zhang, J., Houslay, M.D., Chao, M.V. and Akassoglou, K. (2007) p75 neurotrophin receptor regulates tissue fibrosis through inibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J. Cell Biol. 177, 1119-1132.

Rantamaki, T., Hendolin, P., Kankaanpaa, A., Mijatovic, J., Piepponen, P., Domenici, E., Chao, M.V., Mannisto, P.T. and Castren, E. (2007) Pharmacologically diverse antidepressants rapidly activate BDNF receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain. Neuropsychopharm 32, 2152-2162.

Urra, S., Escudero, C.A., Ramos, P., Lisbona, F., Allende E., Covarrubias, P., Parraguez, J.I., Zampieri, N., Chao, M.V., Annaert, W. and Bronfman, F.C. (2007) TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intacellular domain. J. Biol. Chem. 282, 7606-7615.

Pereira, D.B. and Chao, M.V. (2007) The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts.  J. Neuroscience 27, 4859-4869. 

Cortes, R.Y., Arevalo, J.C., Magby, J.P., Chao, M.V. and Plummer, M.R. (2007) Developmental andactivity-dependent regulation of ARMS/Kidins220 in cultured rat hippocampal neurons.  Dev.
Neurobiol., ahead of print.

Domeniconi, M., Hempstead, B.L. and Chao, M.V. (2007) Pro-NGF secreted by astrocytes promotes motor neuron cell death.  Mol. Cell. Neuroscience 34, 271-279.

Zampieri, N. and Chao, M.V. (2006) Mechanisms of neurotrophin receptor signaling.  Biochem. Soc.Trans. 34, 607-611. 

Jeanneteau, F. and Chao, M.V. (2006) Promoting neurotrophic effects by GPCR ligands.  Novartis Found.Symp. 276, 181-189.

Yano, H., Ninan, I., Zhang, H., Milner, T.A., Arancio, O., Chao, M.V. (2006) BDNF-mediated
neurotransmission relies upon a myosin VI motor complex.  Nature Neurosci 9, 1009-1018. 

Arevalo, J.C., Waite, J., Rajagopal, R., Beyna, M., Chen, Z-Y., Lee, F.S. and Chao, M.V. (2006) Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 50, 549-559.

Rajagopal, R. and Chao, M.V. (2006) A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling.  Mol. Cell. Neurosci 33, 36-46. 

Arevalo, J.C., Waite, J., Rajagopal, R., Beyna, M., Chen, Z-Y., Lee, F.S. and Chao, M.V. (2006) Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 50, 549-559.

Arevalo, J.C., Pereira, D., Yano, H., Teng, K.K. and Chao, M.V. (2006) Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation, J. Biol Chem.281, 1001-1007.

Zampieri, N., Xu, C., Neubert, T.A., Chao, M.V. (2005) Cleavage of p75 neurotrophin receptor by alpha secretase and gamma-secretase requires specific receptor domains.  J Biol Chem 280, 14563- 14571.

Chang, M.S., Arevalo, J.C. and Chao, M.V. (2004) Ternary complex with Trk, p75 and an ankyrin-rich membrane spanning protein.  J Neurosci Res 78, 186-192. 

Rajagopal, R., Chen, Z-Y., Lee, F.S. and Chao, M.V. (2004) Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes.  J. Neuroscience 24, 6650-6658.

Murray, S., Perez, P., Lee, R., Hempstead, B.L. and Chao, M.V. (2004) A novel p75 neurotrophin receptor related protein, NRH2, regulates NGF binding to the TrkA receptor.  J Neuroscience 24, 2742=2749.

Arevalo, J.C., Yano, H., Teng, K.K., Chao, M.V. (2004) A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane spanning protein.  EMBO J 23, 2358-2368.  

Akassoglou, K., Malester, B., Xu, J., Tessarollo, L., Rosenbluth, J. and Chao, M.V. (2004) Brain-specific deletion of Neuropathy Target Esterase/swisscheese results in neurodegeneration.  Proc Natl Acad Sci USA 101, 5075-5080. 

Murray, S., Perez, P., Lee, R., Hempstead, B.L. and Chao, M.V. (2004) A novel p75 neurotrophin receptor related protein, NRH2, regulates NGF binding to the TrkA receptor.  J Neuroscience 24, 2742-2749.

Review Articles

Arancio, O. and Chao, M.V. (2007) Neurotrophins, synaptic plasticity, and dementia.  Current Opinion in Neurobiol, 17,  325-330.

Chao, M.V., Rajagopal, R. and Lee, F.S. (2005) Neurotrophin signaling in health and disease.  Clinical Science 110, 167-173. 

Arevalo, J.C. and Chao, M.V. (2005) When neurotrophins meet Wnts.  Current Opinion Cell Biol 7, 112-115.

Chao, M.V. and Lee, F.S. (2004) Neurotrophin survival signaling mechanisms.  J Alzheimers Disease, S7-S11.

Zampieri, N. and Chao, M.V. (2004) The p75 NGF receptor exposed.  Science 304, 833-834. 

Schiavo, G. and Chao, M.V. (2004) Motors, adaptors, and receptors: Key elements of neuronal transport.  J   Neurobiology 58, 161-163.

Chao, M.V. (2003) Dependence receptors: what is the mechanism?  Science STKE, PE38.

Chao, M.V. (2003).  Retrograde transport redux.  Neuron 39, 1-2. 

Chao, M.V. (2003) Neurotrophins and their receptors: A convergence point for many signaling pathways. Nature Rev Neuroscience 4, 299-309.

Chao, M.V. and Bothwell, M. (2002) Neurotrophins: To cleave or not to cleave.  Neuron 33, 9-12.