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Liang Zhou
Postdoctoral Fellow
Ph.D. University of California, Los Angeles. 2004
M. D. Nanjing Medical University. China. 1996
Liang.Zhou@med.nyu.edu

My research interests involve studying molecular mechanisms of TH17 program differentiation, focusing on identification and characterization of transcriptional regulatory networks.  These studies will deepen our understanding of both immune system development and regulation of host immunity against various pathogens.

Publications

Zhou, L., Lopes, J., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J.,Rubtsov, Y. P., Rudensky, A. Y., Ziegler, S. F., Littman, D. R. TGF-b-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORgt function.  Nature.  453 (7192), 236-40 (2008).

Ivanov I. I., Zhou, L., Littman, D. R.  Transcriptional regulation of TH17 cell differentiation.  Semin. Immunol.  19 (6), 409-17 (2007).

Zhou, L., Ivanov, I. I., Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., Littman, D. R.  IL-6 programs TH17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.  Nat. Immunol.  8 (9), 967-74 (2007).

Zhou, L., Nazarian, A. A., Xu, J., Tantin, D, Corcoran, L. M., Smale, S. T.  An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment.  Mol. Cell. Biol.  27 (7), 2698-712 (2007).

Ivanov, I. I.*, McKenzie, B. S.*, Zhou. L. *, Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., Littman, D. R.  The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells.  Cell.  126 (6) 1121-33 (2006).  *equal contributions

Sanjabi, S., Williams, K., Saccani, S., Hoffmann, A., Zhou, L., Gerondakis, S., Baltimore, D., Natoli, G., Smale, S. T.  A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.  Genes Dev.  9 (18), 2138-51 (2005).

Zhou, L., Nazarian, A. A., Smale, S. T.  Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway.  Mol. Cell. Biol.  24 (6), 2385-96 (2004).

Bradley, M. N., Zhou, L., Smale, S. T.  C/EBPb regulation in lipopolysaccharide-stimulated macrophages.  Mol. Cell. Biol.  23 (14), 4841-58 (2003).

Yu, M. C., Orlando, T. C., Sturm, N. R., Zhou, L., Saito, R. M., Floeter-Winter, L. M., Campbell, D. A.  Two distinct functional spliced leader RNA gene arrays in Leishmania tarentolae are found in several lizard Leishmania species.  Int. J. Parasitol.  32 (11), 1411-22 (2002).

Feng, H., Zhong, W., Punkosdy, G., Gu, S., Zhou, L., Seabolt, E. K., Kipreos, E. T.  CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.  Nat. Cell Biol.  1 (8), 486-92 (1999).