Additional Publications

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T cell antigen receptor signaling

Sims TN, Soos TJ, Xenias HS, Dubin-Thaler B, Hofman JM, Waite JC, Cameron TO, Thomas VK, Varma R, Wiggins CH, Sheetz MP, Littman DR, Dustin ML. Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell. 2007 May 18;129(4):773-85. [download PDF]

Misra RS, Russell JQ, Koenig A, Hinshaw-Makepeace JA, Wen R, Wang D, Huo H, Littman DR, Ferch U, Ruland J, Thome M, Budd RC.  Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. J Biol Chem. 2007 Jul 6;282(27):19365-74. Epub 2007 Apr 26. [download PDF]

Littman DR, Singh H.  Immunology. Asymmetry and immune memory. Science. 2007 Mar 23;315(5819):1673-4. [download PDF]

Berg-Brown, N.N., Gronski, M.A., Jones, R.G., Elford, A.R., Deenick, E.K., Odermatt, B., Littman, D.R., Ohashi, P.S. (2004) PKC-q activation verses tolerance in vivo. JEM 199 (6), 743-752. [download PDF]

Egawa, T., Albrecht, B., Favier, B., Sunshine, M.J., Mirchandani, K., O'Brien, W., Thome, M., Littman, D.R. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr. Biology. 13 (14), 1252-1258. [download PDF]

Arendt, C.W., Albrecht, B., Soos, T.J., & Littman, D.R. (2002) Protein Kinase C-q: Signaling from the center of the T-cell synapse. Curr. Opin. Immunol. 14, 323-330.[download PDF]

Sun, Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P.L., & Littman, D.R. (2000) PKC-q is required for TCR-induced NF-kB activation in mature but not immature T lymphocytes. Nature 404, 402-407. [download PDF]

Ellmeier, W., Sunshine, M.J., Jung, S., Hatam, F., Xu, Y., Baltimore, D., Mano, H., & Littman, D.R. (2000). Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk. J. Exp. Med. 192, 1611-1624. [download PDF]

Bachmann, M.F., Littman, D.R., & Liao, X.C. (1997) Anti-viral immune responses in Itk-deficient mice. J. Virol. 71, 7253-7257. [download PDF]

Liao, C. & Littman, D. R. (1995) Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 3, 757-769. [download PDF]

Crooks, C., & Littman, D. (1994) Disruption of T lymphocyte positive and negative selection in mice lacking the CD8b chain. Immunity 1, 277-285. [download PDF]

Xu, H., & Littman, D.R. (1993). A kinase-independent function of lck in potentiating antigen-specific T cell activation. Cell 74, 633-644. [download PDF]

Glaichenhaus, N., Shastri, N., Littman, D.R. & Turner, J.M. (1991) Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells. Cell 64, 511-520. [download PDF]

Turner, J.M., Brodsky, M.H., Irving, B.A., Levin, S.D., Perlmutter, R.M. & Littman, D.R. (1990) Interaction of the unique amino-terminal region of the tyrosine kinase p56lck with the cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60, 755-765. [download PDF]

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Chemokine receptors and related murine models - back to top

 

Cardona, A.E., Pioro, E.P., Sasse, M.E., Kostenko, V., Cardona, S.M., Dijkstra, I.M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., Lee, J.C., Cook, D.N., Jung, S., Lira, S.A., Littman, D.R., Ransohoff, R.M. (2006) Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci. 2006 Jul;9(7):917-24. Epub 2006 Jun 18. [download PDF]

Davalos, D., Grutzendler, J., Yang, G., Kim, J.V., Zuo, Y., Jung, S., Littman, D.R., Dustin, M.L., Gan, W.B. (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci. 2005 Jun;8(6):752-8. Epub 2005 May 15. [download PDF]

Geissmann, F., Cameron, T.O., Sidobre, S., Manlongat, N., Kronenberg, M., Briskin, M.J., Dustin, M.L., Littman, D.R. (2005) Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol. 3(4), 650-661. [download PDF]

Zaft, T., Sapoznikov, A., Krauthgamer, R., Littman, D.R., Jung, S. (2005) CD11c high dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J Immunol. 2005 Nov 15;175(10):6428-35. [download PDF]

Niess, J.H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B.A., Vyas, J.M., Boes, M., Ploegh, H.L., Fox, J.G., Littman, D.R., & Reinecker, H.C. (2005) CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307, 254-258. [download PDF]

Nie, Y., Waite, J., Brewer, F., Sunshine, M.J., Littman, D.R., Zou, Y.R. (2004) The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med. 200(9), 1145-56. [download PDF]

Geissmann, F., Jung, S., Littman, D.R. (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 19, 71-82. [download PDF]

Jung, S., Unutmaz, D., Wong, P., Sano, G.I., De los Santos, K., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., Pamer, E.G., Littman, D.R., & Lang, R. (2002) In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity, 17, 211-220. [download PDF]

Palframan, R.T., Jung, S., Cheng, G., Weninger, W., Luo, Y., Dorf, M., Littman, D.R., Rollins, B., Zweerink, H., Rot, A., & von Andrian, U.H. (2001) Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J. Exp. Med. 194, 1361-1374.[download PDF]

Jung, S., Aliberti, J., Graemmel, P., Sunshine, M.J., Kreutzberg, G.W., Sher, A., & Littman, D.R. (2000) Analysis of fractalkine receptor CX3CR1 function by targeted deletion and GFP reporter gene insertion. Mol. Cell. Biol. 20, 4106-14. [download PDF]

Jung, S. & Littman, D.R. (1999) Chemokine receptors in lymphoid organ homeostasis. Curr. Opin. Immunol. 11, 319-25.

Zou, Y.R., Kottmann, A., Kuroda, M., Taniuchi, I., & Littman, D.R. (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393, 595-599. [download PDF]

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