Early T Cell Development: Transcriptional Networks, Epigenetic Regulation, & Roles of Small RNAs - Publications - Description
Th17, T-Regs, & Maintenance of Immune Homeostasis in Peripheral Tissues - Publications - Description
Mechanisms of HIV Pathogenesis and Anti-retroviral Immunity - Publications - DescriptionAdditional Publications
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Early T Cell Development: Transcriptional Networks, Epigenetic Regulation, & Roles of Small RNAs - back to top Amélie Collins, Dan R. Littman1, Ichiro Taniuchi. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nature Reviews Immunology 9, 106-115 Feb 2009 [download PDF] Egawa T, Littman DR. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol. 2008 Oct;9(10):1131-9. Epub 2008 Sep 7. [download PDF] Chong MM, Rasmussen JP, Rudensky AY, Littman DR. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med. 2008 Sep 1;205(9):2005-17. Epub 2008 Aug 25. doi: 10.1084/jem.20071219090508c. [download PDF] Egawa T, Kreslavsky T, Littman DR, von Boehmer H. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage
fate mapping.
PLoS ONE. 2008 Jan 30;3(1):e1512. Egawa T, Tillman RE, Naoe Y, Taniuchi I, Littman DR. The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med. 2007 Aug 6;204(8):1945-57. Epub 2007 Jul 23. [download PDF] Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, Littman DR, Taniuchi I. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med. 2007 Aug 6;204(8):1749-55. Epub 2007 Jul 23. [download PDF] Collins, A., & Littman, D.R. (2005) Selection and lineage specification in the thymus: commitment 4-stalled. Immunity. 2005 Jul;23(1):4-5. [download PDF] Grueter, B., Petter, M., Egawa, T., Laule-Kilian, K., Aldrian, CJ., Wuerch, A., Ludwig, Y., Fukuyama, H., Wardemann, H., Waldschuetz, R., Moroy, T., Taniuchi, I., Steimle, V., Littman, D.R., & Ehlers, M. (2005) Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol. 2005 Aug 1;175(3):1694-705. Erratum in: J Immunol. 2005 Nov 1;175(9):6238. [download PDF] Egawa, T., Eberl, G., Taniuchi, I., Benlagha, K., Geissmann, F., Hennighausen, L., Bendelac, A., & Littman, D.R. (2005) Genetic evidence supporting selection of the V alpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity.2005 Jun:22(6): 705-16. [download PDF] Wang, X., Blagden, C., Fan, J., Nowak, S.J., Taniuchi, I., Littman D.R., Burden, S.J. (2005) Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes Dev. 2005 Jul 15;19(14):1715-22. [download PDF] Marsland, B.J., Soos, T.J., Spath, G., Littman, D.R., Kopf, M. (2004) Protein Kinase C-theta is critical for the development of in vivo T helper (Th) 2 cell but not Th1 cell responses. JEM 200 (2),181-189.[download PDF] Taniuchi, I., Ellmeier, W., & Littman, D.R. (2004) The CD4 / CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv Immunol 83, 55-89. [download PDF] Taniuchi, I., Osato, M., Egawa, T., Sunshine, M.J., Bae, S.-C., Komori, T., Ito, Y., & Littman, D.R. (2002) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621-633 [download PDF] Taniuchi, I., Sunshine, M.J., Festenstein, R., & Littman, D.R. (2002) Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Molecular Cell 10, 1083-1096 [download PDF] Chi, T.H., Wan, M., Zhao, K., Taniuchi, I., Lee, P.P., Akashi, K., Metzger, D., Wilson, C.B., Chambon, P., Littman, D.R. & Crabtree, G.R. (2002) Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature 418, 195-199.[download PDF] Guo, J., Hawwari, A., Li., H., Sun, Z., Mahanta, S.K., Littman, D.R., Krangel, M.S., & He, Y.-W. (2002) Regulation of the TCRa repertoire by the survival window of CD4+CD8+ thymocytes. Nature Immunology 3, 469-476. [download PDF] Ellmeier, W., Sunshine, MJ., Maschek, R., Littman, DR. (2002) Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16, 623-634. [download PDF] Zou, Y.R., Sunshine, M.J., Taniuchi, I., Hatam, F., Killeen, N., & Littman, D.R. (2001) The CD4 gene is epigenetically silenced in T cells committed to the cytotoxic lineage. Nature Genetics 29, 332-336. [download PDF] Ellmeier, W., Sawada, S., & Littman, D.R. (1999) The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Ann. Rev. Immunol. 17, 523-554.[download PDF] Ellmeier, W., Sunshine, M.J., Losos, K., & Littman, D.R. (1998) Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity 9, 485-496. [download PDF] Riviere, I., Sunshine, M.J., & Littman, D.R. (1998) Regulation of IL-4 expression by activation of individual alleles. Immunity 9, 217-228. [download PDF] Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F. & Littman, D.R. (1997) Identification of an enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 7, 537-547. [download PDF] Sawada, S., Scarborough, J.D., Killeen, N., & Littman, D.R. (1994) A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77, 917-929. [download PDF] Davis, C.B., Killeen, N., Crooks, M.E.C., Raulet, D., & Littman, D.R. (1993) Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73, 237-47. [download PDF] Killeen, N., & Littman, D.R. (1993) Helper T cell development in the absence of CD4-p56lck association. Nature 364, 729-732. [download PDF] Sawada, S., & Littman, D.R. (1993) A Heterodimer of HEB and an E12-Related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell. Biol. 13, 5620-5628. [download PDF] Sawada, S., & Littman, D.R. (1991) Identification and characterization of a T cell specific enhancer adjacent to the murine CD4 gene. Mol. Cell. Biol. 11, 5506-5515. [download PDF]
Th17, T-Regs, & Maintenance of Immune Homeostasis in Peripheral Tissues - back to top Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity. 2009 May;30(5):646-55. Review. [download PDF] Zhou L, Littman DR. Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol. 2009 Apr;21(2):146-52. Epub 2009 Mar 26. Review. [download PDF] Voo KS, Wang YH, Santori FR, Boggiano C, Wang YH, Arima K, Bover L, Hanabuchi S, Khalili J, Marinova E, Zheng B, Littman DR, Liu YJ. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4793-8. Epub 2009 Mar 9. [download PDF] Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008 Oct 16;4(4):337-49. [download PDF] Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol. 2008 Jun;9(6):641-9. Epub 2008 May 4. [download PDF] Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, Ziegler SF, Littman DR. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008 May 8;453(7192):236-40. Epub 2008 Mar 26. [download PDF] Luci C, Reynders A, Ivanov II, Cognet C, Chiche L, Chasson L, Hardwigsen J, Anguiano E, Banchereau J, Chaussabel D, Dalod M, Littman DR, Vivier E, Tomasello E. Influence of the transcription factor RORgammat on the development of NKp46(+) cell populations in gut and skin. Nat Immunol. 2008 Nov 23. [download PDF] Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF. RORgamma-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F. Gastroenterology. 2008 Oct 9. [download PDF] Quezada SA, Peggs KS, Simpson TR, Shen Y, Littman DR, Allison JP. Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J Exp Med. 2008 Sep 1;205(9):2125-38. Epub 2008 Aug 25. [download PDF] Tsuji M, Suzuki K, Kitamura H, Maruya M, Kinoshita K, Ivanov II, Itoh K, Littman DR, Fagarasan S. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity. 2008 Aug;29(2):261-71. Epub 2008 Jul 24. [download PDF] Valdez Y, Diehl GE, Vallance BA, Grassl GA, Guttman JA, Brown NF, Rosenberger CM, Littman DR, Gros P, Finlay BB. Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection. Cell Microbiol. 2008 Aug;10(8):1646-61. Epub 2008 Apr 7. [download PDF] Ivanov II, Zhou L, Littman DR. Transcriptional regulation of Th17 cell differentiation. Semin Immunol. 2007 Dec;19(6):409-17. Epub 2007 Nov 28. Review. [download PDF] Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007 Sep;8(9):967-74. Epub 2007 Jun 20. [download PDF] Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. (2007) IL-6 programs T(H)-17 cell differentiation by promoting engagement of IL-21 and IL-23 pathways. Nat Immunol. [download PDF] Ivanov, I.I., McKenzie, B.S., Zhou, L., Tadokoro, C., Lepelley, A., Lafaille, J.J., Cua, D.J., & Littman, D.R. (2006) The orphan nuclear receptor RORgt directs the differentiation program of pro-inflammatory IL-17+ T helper cells. CELL.2005, 126(6):1121-33. [download PDF] Ivanov, I.I., Diehl, G.E., Littman, D.R. (2006) Lymphoid Tissue Inducer Cells in Intestinal Immunity. CTMI 308:59-82. [download PDF] Eberl, G., Littman, D.R. (2004) Thymic origin of intestinal abT cells revealed by fate mapping of RORgt cells. Science 305, 248-251. [download PDF] Eberl, G., Marmon, S., Sunshine, M.J., Rennert, P.D., Littman, D.R. (2004) Essential function for the nuclear receptor RORg in the generation of fetal lymphoid tissue inducer cells. Nature Immunology 5(1), 64-73. [download PDF] Eberl, G. and Littman, D.R. (2003) The role of the nuclear hormone receptor RORg in the development of lymph nodes and Peyer's patches. Immunol Rev. 195. 81-90. [download PDF] Harmsen, A., Kusser, K., Hartson, L., Tighe, M., Sunshine, M.J, Sedgwick, J.D., Choi, Y., Littman, D.R. & Randall, T.D. (2002) Organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-a (LTa) and retinoic acid receptor-related orphan receptor-g, but the organization of NALT is LTa dependent. J. Immunol., 168, 986-990. [download PDF] Sun, Z., Unutmaz, D., Zou, Y.R., Sunshine, M.J., Pierani, A., Brenner-Morton, S., Mebius, R.E., & Littman, D.R. (2000) Requirement for RORg in thymocyte survival and lymphoid organ development. Science 288, 2369-2373. [download PDF]
------ Mechanisms of HIV Pathogenesis and Anti-retroviral Immunity - back to top Browne EP, Littman DR. Myd88 is required for an antibody response to retroviral infection. PLoS Pathog. 2009 Feb;5(2):e1000298. Epub 2009 Feb 13. [download PDF] Zhang JX, Diehl GE, Littman DR. Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells. PLoS ONE. 2008 Apr 30;3(4):e2035. [download PDF] Browne EP, Littman DR. Species-specific restriction of apobec3-mediated hypermutation. J Virol. 2008 Feb;82(3):1305-13. Epub 2007 Nov 21. [download PDF] Boggiano C, Littman DR. HIV's vagina travelogue. Immunity. 2007 Feb;26(2):145-7. Review. [download PDF] Boggiano C, Manel N, Littman DR. Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN. J Virol. 2007 Mar;81(5):2519-23. Epub 2006 Dec 20. [download PDF] Soos, T.J., Sims, T.N., Barisoni, L., Lin, K., Littman, D.R., Dustin, M.L., Nelson, P.J. (2006) CX(3)CR1(+) interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int. 2006 Jun 7. [download PDF] Sun, J., Soos, T., Kewalramani, V.N., Osiecki, K., Zheng, J.H., Falkin, L., Santambrogio, L., Littman, D.R., Goldstein, H. (2006) CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate. J Virol. 2006 Feb;80(4):1850-62. [download PDF] Kwon, D.S, Gregario, G., Bitton, N., Hendrickson, W.A., & Littman, D.R. (2002) DC-SIGN mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity 16, 135-44. [download PDF] Geijtenbeek, T.B.H., Kwon, D.S., Torensma, R., van Vliet, S.J., van Duijnhoven, G.C.F., Middel, J., Cornelisen, I.L.M.H.A., Nottet, H.S.L.M., KewalRamani, V.N., Littman, D.R., Figdor, C.G., & van Kooyk, Y.(2000) DC-SIGN, a dendritic cell-specific HIV-1 binding protein that enhances rans infection of T cells. Cell 100, 587-597. [download PDF] Unutmaz, D., Xiang, W., Sunshine, M.J., Campbell, J., Butcher, E. & Littman, D.R. (2000) The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. J. Immunol. 165, 3284-92. [download PDF] Jung, S., Littman, D.R. (1999) Chemokine receptors in lymphoid organ homeostasis. Curr Opin Immunol. 1999 Jun;11(3):319-25. Review. [download PDF] Unutmaz, D., KewalRamani, V.N., Marmon, S., & Littman, D.R. (1999) Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J. Exp. Med. 189, 1735-46. [download PDF] Davis, C.B., Dikic, I., Unutmaz, D., Hill, C.M., Siani, M., Schlessinger, J., & Littman, D.R. (1997) Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5. J. Exp. Med. 186, 1793-1798. [download PDF] Deng, H.K., Unutmaz, D., KewalRamani, V.N., & Littman, D.R. (1997) Expression cloning of novel receptors used by the simian and human immunodeficiency viruses. Nature 388, 296-300. [download PDF] Hill, C.M., Deng, H.K., Unutmaz, D., Kewalramani, V., Bastiani, L., Zolla-Pazner, S., & Littman, D.R. (1997) Envelope glycoproteins from HIV-1, HIV-2, and SIV can use human CCR5 as a cofactor for viral entry and make direct CD4-dependent interactions with this chemokine receptor. J. Virol. 71, 6296-6304. [download PDF] Deng, H.K., Rong, L., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B., Peiper, S.C. Schall, T.J., Littman, D.R., & Landau, N.R. (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.[download PDF]
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