T cell antigen receptor signalingMarsland, B.J., Soos, T.J., Spath, G., Littman, D.R., Koph, M. (2004) Protein Kinase C q is critical for the development of in vivo T helper (Th) 2 cell but not Th1 cell responses. JEM 200 (2),181-189.[download PDF]
Berg-Brown, N.N., Gronski, M.A., Jones, R.G., Elford, A.R., Deenick, E.K., Odermatt, B., Littman, D.R., Ohashi, P.S. (2004) PKC-q activation verses tolerance in vivo. JEM 199 (6), 743-752. [download PDF]
Egawa, T., Albrecht, B., Favier, B., Sunshine, M.J., Mirchandani, K., O'Brien, W., Thome, M., Littman, D.R. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr. Biology. 13 (14), 1252-1258. [download PDF]
Arendt, C.W., Albrecht, B., Soos, T.J., & Littman, D.R. (2002) Protein Kinase C-q: Signaling from the center of the T-cell synapse. Curr. Opin. Immunol. 14, 323-330.[download PDF]
Sun, Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P.L., & Littman, D.R. (2000) PKC-q is required for TCR-induced NF-kB activation in mature but not immature T lymphocytes. Nature 404, 402-407. [download PDF]
Ellmeier, W., Sunshine, M.J., Jung, S., Hatam, F., Xu, Y., Baltimore, D., Mano, H., & Littman, D.R. (2000). Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk. J. Exp. Med. 192, 1611-1624. [download PDF]
Bachmann, M.F., Littman, D.R., & Liao, X.C. (1997) Anti-viral immune responses in Itk-deficient mice. J. Virol. 71, 7253-7257. [download PDF]
Liao, C. & Littman, D. R. (1995) Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 3, 757-769. [download PDF]
Crooks, C., & Littman, D. (1994) Disruption of T lymphocyte positive and negative selection in mice lacking the CD8b chain. Immunity 1, 277-285. [download PDF]
Killeen, N., & Littman, D.R. (1993) Helper T cell development in the absence of CD4-p56lck association. Nature 364, 729-732. [download PDF]
Xu, H., & Littman, D.R. (1993). A kinase-independent function of lck in potentiating antigen-specific T cell activation. Cell 74, 633-644. [download PDF]
Glaichenhaus, N., Shastri, N., Littman, D.R. & Turner, J.M. (1991) Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells. Cell 64, 511-520. [download PDF]
Turner, J.M., Brodsky, M.H., Irving, B.A., Levin, S.D., Perlmutter, R.M. & Littman, D.R. (1990) Interaction of the unique amino-terminal region of the tyrosine kinase p56lck with the cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60, 755-765. [download PDF]
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Lineage commitment, gene silencing, and epigenetic regulation in thymocytes
Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. (2007) IL-6 programs T(H)-17 cell differentiation by promoting engagement of IL-21 and IL-23 pathways. Nat Immunol. Epub ahead of print. [download PDF]
Ivanov, I.I., McKenzie, B.S., Zhou, L., Tadokoro, C., Lepelley, A., Lafaille, J.J., Cua, D.J., & Littman, D.R. (2006) The orphan nuclear receptor RORgt directs the differentiation program of pro-inflammatory IL-17+ T helper cells. CELL.2005, 126(6):1121-33. [download PDF]
Egawa, T., Eberl, G., Taniuchi, I., Benlagha, K., Geissmann, F., Hennighausen, L., Bendelac, A., & Littman, D.R. (2005) Genetic evidence supporting selection of the V alpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity.2005 Jun:22(6): 705-16. [download PDF]
Collins, A., & Littman, D.R. (2005) Selection and lineage specification in the thymus: commitment 4-stalled. Immunity. 2005 Jul;23(1):4-5. [download PDF]
Grueter, B., Petter, M., Egawa, T., Laule-Kilian, K., Aldrian, CJ., Wuerch, A., Ludwig, Y., Fukuyama, H., Wardemann, H., Waldschuetz, R., Moroy, T., Taniuchi, I., Steimle, V., Littman, D.R., & Ehlers, M. (2005) Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol. 2005 Aug 1;175(3):1694-705. Erratum in: J Immunol. 2005 Nov 1;175(9):6238. [download PDF]
Wang, X., Blagden, C., Fan, J., Nowak, S.J., Taniuchi, I., Littman D.R., Burden, S.J. (2005) Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes Dev. 2005 Jul 15;19(14):1715-22. [download PDF]
Taniuchi, I., Ellmeier, W., & Littman, D.R. (2004) The CD4 / CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv Immunol 83, 55-89. [download PDF]
Taniuchi, I., Osato, M., Egawa, T., Sunshine, M.J., Bae, S.-C., Komori, T., Ito, Y., & Littman, D.R. (2002) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621-633 [download PDF]
Taniuchi, I., Sunshine, M.J., Festenstein, R., & Littman, D.R. (2002) Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Molecular Cell 10, 1083-1096 [download PDF]
Chi, T.H., Wan, M., Zhao, K., Taniuchi, I., Lee, P.P., Akashi, K., Metzger, D., Wilson, C.B., Chambon, P., Littman, D.R. & Crabtree, G.R. (2002) Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature 418, 195-199.[download PDF]
Guo, J., Hawwari, A., Li., H., Sun, Z., Mahanta, S.K., Littman, D.R., Krangel, M.S., & He, Y.-W. (2002) Regulation of the TCRa repertoire by the survival window of CD4+CD8+ thymocytes. Nature Immunology 3, 469-476. [download PDF]
Ellmeier, W., Sunshine, MJ., Maschek, R., Littman, DR. (2002) Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16, 623-634. [download PDF]
Zou, Y.R., Sunshine, M.J., Taniuchi, I., Hatam, F., Killeen, N., & Littman, D.R. (2001) The CD4 gene is epigenetically silenced in T cells committed to the cytotoxic lineage. Nature Genetics 29, 332-336. [download PDF]
Ellmeier, W., Sawada, S., & Littman, D.R. (1999) The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Ann. Rev. Immunol. 17, 523-554.[download PDF]
Ellmeier, W., Sunshine, M.J., Losos, K., & Littman, D.R. (1998) Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity 9, 485-496. [download PDF]
Riviere, I., Sunshine, M.J., & Littman, D.R. (1998) Regulation of IL-4 expression by activation of individual alleles. Immunity 9, 217-228. [download PDF]
Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F. & Littman, D.R. (1997) Identification of an enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 7, 537-547. [download PDF]
Sawada, S., Scarborough, J.D., Killeen, N., & Littman, D.R. (1994) A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77, 917-929. [download PDF]
Davis, C.B., Killeen, N., Crooks, M.E.C., Raulet, D., & Littman, D.R. (1993) Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73, 237-47. [download PDF]
Sawada, S., & Littman, D.R. (1993) A Heterodimer of HEB and an E12-Related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell. Biol. 13, 5620-5628. [download PDF]
Sawada, S., & Littman, D.R. (1991) Identification and characterization of a T cell specific enhancer adjacent to the murine CD4 gene. Mol. Cell. Biol. 11, 5506-5515. [download PDF]
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Development and function of organized MALT
Ivanov, I.I., Diehl, G.E., Littman, D.R. (2006) Lymphoid Tissue Inducer Cells in Intestinal Immunity. CTMI 308:59-82. [download PDF]
Eberl, G., Littman, D.R. (2004) Thymic origin of intestinal abT cells revealed by fate mapping of RORgt cells. Science 305, 248-251. [download PDF]
Eberl, G., Marmon, S., Sunshine, M.J., Rennert, P.D., Littman, D.R. (2004) Essential function for the nuclear receptor RORg in the generation of fetal lymphoid tissue inducer cells. Nature Immunology 5(1), 64-73. [download PDF]
Eberl, G. and Littman, D.R. (2003) The role of the nuclear hormone receptor RORg in the development of lymph nodes and Peyer's patches. Immunol Rev. 195. 81-90. [download PDF]
Harmsen, A., Kusser, K., Hartson, L., Tighe, M., Sunshine, M.J, Sedgwick, J.D., Choi, Y., Littman, D.R. & Randall, T.D. (2002) Organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-a (LTa) and retinoic acid receptor-related orphan receptor-g, but the organization of NALT is LTa dependent. J. Immunol., 168, 986-990. [download PDF]
Sun, Z., Unutmaz, D., Zou, Y.R., Sunshine, M.J., Pierani, A., Brenner-Morton, S., Mebius, R.E., & Littman, D.R. (2000) Requirement for RORg in thymocyte survival and lymphoid organ development. Science 288, 2369-2373. [download PDF]
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Role of DC in T cell priming and HIV infection
Soos, T.J., Sims, T.N., Barisoni, L., Lin, K., Littman, D.R., Dustin, M.L., Nelson, P.J. (2006) CX(3)CR1(+) interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int. 2006 Jun 7. [download PDF]
Zaft, T., Sapoznikov, A., Krauthgamer, R., Littman, D.R., Jung, S. (2005) CD11c high dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J Immunol. 2005 Nov 15;175(10):6428-35. [download PDF]
Niess, J.H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B.A., Vyas, J.M., Boes, M., Ploegh, H.L., Fox, J.G., Littman, D.R., & Reinecker, H.C. (2005) CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307, 254-258. [download PDF]
Jung, S., Unutmaz, D., Wong, P., Sano, G.I., De los Santos, K., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., Pamer, E.G., Littman, D.R., & Lang, R. (2002) In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity, 17, 211-220. [download PDF]
Kwon, D.S, Gregario, G., Bitton, N., Hendrickson, W.A., & Littman, D.R. (2002) DC-SIGN mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity 16, 135-44. [download PDF]
Geijtenbeek, T.B.H., Kwon, D.S., Torensma, R., van Vliet, S.J., van Duijnhoven, G.C.F., Middel, J., Cornelisen, I.L.M.H.A., Nottet, H.S.L.M., KewalRamani, V.N., Littman, D.R., Figdor, C.G., & van Kooyk, Y.(2000) DC-SIGN, a dendritic cell-specific HIV-1 binding protein that enhances rans infection of T cells. Cell 100, 587-597. [download PDF]
Jung, S., Littman, D.R. (1999) Chemokine receptors in lymphoid organ homeostasis. Curr Opin Immunol. 1999 Jun;11(3):319-25. Review. [download PDF]
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Chemokine receptors, HIV entry, and related murine models
Sun, J., Soos, T., Kewalramani, V.N., Osiecki, K., Zheng, J.H., Falkin, L., Santambrogio, L., Littman, D.R., Goldstein, H. (2006) CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate. J Virol. 2006 Feb;80(4):1850-62. [download PDF]
Cardona, A.E., Pioro, E.P., Sasse, M.E., Kostenko, V., Cardona, S.M., Dijkstra, I.M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., Lee, J.C., Cook, D.N., Jung, S., Lira, S.A., Littman, D.R., Ransohoff, R.M. (2006) Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci. 2006 Jul;9(7):917-24. Epub 2006 Jun 18. [download PDF]
Davalos, D., Grutzendler, J., Yang, G., Kim, J.V., Zuo, Y., Jung, S., Littman, D.R., Dustin, M.L., Gan, W.B. (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci. 2005 Jun;8(6):752-8. Epub 2005 May 15. [download PDF]
Geissmann, F., Cameron, T.O., Sidobre, S., Manlongat, N., Kronenberg, M., Briskin, M.J., Dustin, M.L., Littman, D.R. (2005) Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol. 3(4), 650-661. [download PDF]
Nie, Y., Waite, J., Brewer, F., Sunshine, M.J., Littman, D.R., Zou, Y.R. (2004) The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med. 200(9), 1145-56. [download PDF]
Geissmann, F., Jung, S., Littman, D.R. (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 19, 71-82. [download PDF]
Palframan, R.T., Jung, S., Cheng, G., Weninger, W., Luo, Y., Dorf, M., Littman, D.R., Rollins, B., Zweerink, H., Rot, A., & von Andrian, U.H. (2001) Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J. Exp. Med. 194, 1361-1374.[download PDF]
Unutmaz, D., Xiang, W., Sunshine, M.J., Campbell, J., Butcher, E. & Littman, D.R. (2000) The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. J. Immunol. 165, 3284-92. [download PDF]
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M.J., Kreutzberg, G.W., Sher, A., & Littman, D.R. (2000) Analysis of fractalkine receptor CX3CR1 function by targeted deletion and GFP reporter gene insertion. Mol. Cell. Biol. 20, 4106-14. [download PDF]
Unutmaz, D., KewalRamani, V.N., Marmon, S., & Littman, D.R. (1999) Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J. Exp. Med. 189, 1735-46. [download PDF]
Jung, S. & Littman, D.R. (1999) Chemokine receptors in lymphoid organ homeostasis. Curr. Opin. Immunol. 11, 319-25.
Zou, Y.R., Kottmann, A., Kuroda, M., Taniuchi, I., & Littman, D.R. (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393, 595-599. [download PDF]
Davis, C.B., Dikic, I., Unutmaz, D., Hill, C.M., Siani, M., Schlessinger, J., & Littman, D.R. (1997) Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5. J. Exp. Med. 186, 1793-1798. [download PDF]
Deng, H.K., Unutmaz, D., KewalRamani, V.N., & Littman, D.R. (1997) Expression cloning of novel receptors used by the simian and human immunodeficiency viruses. Nature 388, 296-300. [download PDF]
Hill, C.M., Deng, H.K., Unutmaz, D., Kewalramani, V., Bastiani, L., Zolla-Pazner, S., & Littman, D.R. (1997) Envelope glycoproteins from HIV-1, HIV-2, and SIV can use human CCR5 as a cofactor for viral entry and make direct CD4-dependent interactions with this chemokine receptor. J. Virol. 71, 6296-6304. [download PDF]
Deng, H.K., Rong, L., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B., Peiper, S.C. Schall, T.J., Littman, D.R., & Landau, N.R. (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.[download PDF]
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