Selected Original Reports:

Oyadomari S, Harding HP, Zhang Y, Oyadomari M and Ron D.  2008.  De-phosphorylation of translation initiation factor 2α (eIF2α) enhances glucose tolerance and attenuates hepato-steatosis in mice. Cell Metab 7:520-532 Download pdf

Yun C, Stanhill A, Yang Y, Zhang Y, Haynes CM, Xu C, Neubert T, Mor A, Philips MR and Ron D.  2008.  Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in C. elegans. Proc Natl Acad Sci U S A 105:7094-7099 Download pdf

Harding HP, Lackey JG, Hsu HC, Zhang Y, Jing D, Xu RM, Damha MJ and Ron D.  2008.  An intact unfolded protein response in Trpt1 knockout mice reveals phylogenetic divergence in pathways for RNA ligation. RNA 14:225-232 Download pdf

Haynes CM, Petrova K, Benedetti C, Yang Y and Ron D.  2007.  ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell. 13:467-480. Download pdf

Stanhill A, Haynes CM, Zhang Y, Min G, Steele MC, Kalinina J, Martinez E, Pickart CM, Kong X.-P, and Ron D. 2006. An arsenite-inducible regulatory particle-associated protein (AIRAP) adapts proteasomes to proteotoxicity. Molecular Cell 23:875-885. Download pdf

Benedetti C, Haynes CM, Yang Y, Harding HP and Ron D. 2006. Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics. 174:229-239. Download pdf

Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harrant H, Garrision JL, Taunton J, Katze MG and Ron D. 2006. Co-Translocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 126:727-739. Download pdf. Also see commentary by Pearce & Hebert, correction of an error and unpublished NEW INFORMATION on P58IPK/DnajC3

Marciniak SM, Garcia-Bonilla L, Hu J, Harding H and Ron D. 2006. Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. J Cell Biol 172:201-9. Download pdf

Harding H, Zhang Y, Khershonsky S, Marciniak SM, Scheuner D, Kaufman RJ, Javitt N, Chang Y-T and Ron D. 2005. Bioactive small molecules reveal antagonism between the integrated stress response and sterol regulated gene expression. Cell Metabolism 2:361-71 (2005). Download pdf

Maurin A, Jousse C, Averous J, Parry L, A B, Cherasse Y, Zeng H, Zhang Y, Harding H, Ron D and Fafournoux P. The GCN2 kinase biases feeding behavior to maintain amino-acid homeostasis in omnivores. Cell Metabolism. 1:273-277 (2005). Download pdf. Also see commentary by Dever and Hinnebusch.

Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP and Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes and Development. 18:3066-3077 (2004). Download pdf

Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP and Ron D. Translational repression mediates activation of Nuclear Factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol. 24:10161-10168 (2004). Download pdf

Lu PD, Harding HP and Ron D. Translation re-initiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol. 167:27-33 (2004). Download pdf

Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP and Ron D. Compartment specific perturbation of protein folding activates genes encoding mitochondrial chaperones. J Cell Sci. 117:4055-4066 (2004). Download pdf

Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D and Harding HP. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J. 23:169-179 (2004). Download pdf

Jousse C, Oyadomari S, Novoa I, Lu PD, Zhang Y, Harding HP and Ron D. Inhibition of a constitutive translation initiation factor 2a phosphatase, CReP, promotes survival of stressed cells. J Cell Biol. 163:767-775 (2003). Download pdf

Novoa I, Zhang Y, Zeng H, Jungreis R, Harding HP and Ron D. Stress-induced gene expression requires programmed recovery from translational repression. EMBO J. 22:1180-1187 (2003). Download pdf

Harding H, Zhang Y, Zeng H, Novoa I, Lu P, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl D, Bell J, Hettmann T, Leiden J and Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Molecular Cell 11:619-633 (2003). Download pdf Also see commentary by Rutkowski & Kaufman. "All Roads Lead to ATF4": Dev Cell 4:442-4 (2003).

Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G. and Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415:92-96 (2002). Download pdf

Urano F, Calfon M, Yoneda T, Yun C, Duke K, Kirali M, Clark SG and Ron D. A survival pathway for C. elegans with a blocked unfolded protein response. J Cell Biol. 158:639-646 (2002). Download pdf

Bertolotti, A., Wang, X., Novoa, I., Jungreis, R., Schlessinger, K., Cho, J.H., West, A. B. and Ron D. Increased sensitivity to dextran sodium sulfate colitis in IRE1b deficient mice J Clin Invest 107:585-593 (2001). Download pdf

Sok, J., Calfon, M., Jinyu, L., Lichtlen, P., Clark, S.G. and Ron D. Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity Cell Stress & Chaperones 6:6-15 (2001). Download pdf

Novoa, I., Zeng, H., Harding, H.P., and Ron, D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2a J Cell Biol 153: 1011-1021 (2001). Download pdf Also see the accompanying "in brief" commentary)

Harding, H.P., Zeng, H., Zhang, Y., Jungries, R., Chung, P., Plesken, H., Sabatini, D.D. and Ron, D. Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in survival of secretory cells. Molecular Cell 7: 1153-1163 (2001). Download pdf

Bertolotti, A., and Ron, D. Alterations in an IRE1-RNA complex in the mammalian unfolded protein response. J Cell Sci 114:3207-3212 (2001). Download pdf

Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H.P. and Ron, D. Coupling of Stress in the Endoplasmic Reticulum to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1. Science 287:664-666 (2000). Download pdf

Kuroda, M., Sok, J., Webb, L., Baechtold, H., Urano, F., Yin, Y., Chung, P., Akhmedov, A., de Rooij, D.G., Ashley, T. and Ron, D. Male sterility and enhanced radiation sensitivity in TLS-/- mice. EMBO J 19:453-462 (2000). Download pdf

Harding, H., Novoa, I., Zhang, Y., Zeng, H., Schapira, M., and Ron, D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Molecular Cell 6: 1099-1108 (2000). Download PDF

Bertolotti, A., Zhang, Y., Hendershot, L.M., Harding, H.P., and Ron, D. Dynamic interaction of BiP and the ER stress transducers in the unfolded protein response. Nature Cell Biology 2: 326-332 (2000). Download pdf

Harding, H.P., Zhang, Y., Bertolotti, A., Zeng, H., and Ron, D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Molecular Cell 5: 897-904 (2000). Download pdf

Harding HP, Zhang Y and Ron D. Translation and protein folding are coupled by an endoplasmic reticulum kinase. Nature 397:271-274 (1999). Download pdf. Also see accompanying commentary.

Kuroda, M., Wang, X., Sok, J., Yin, Y., Chung, P., Giannotti, J., Jacobs, K.A., Fitz, L.J., Murtha-Riel, P., Turner, K.J. and Ron, D. Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc. Natl. Acad. Sci. USA 96:5025-5030 (1999). Download pdf

Zinszner, H. et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12, 982-995 (1998). Download pdf

Wang, X.-Z. et al. Identification of novel stress-induced genes downstream of chop. EMBO J 17, 3619-3630 (1998). Download pdf

Wang, X.-Z., Harding, H., Zhang, Y., Jolicoeur, E. & Ron, D. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J 17, 5708-5717 (1998). Download pdf

Wang, X.-Z. et al. Signals from the stressed endoplasmic reticulum induce C/EBP homologous protein (CHOP/GADD153). Mol Cell Biol 16, 4273-4280 (1996).

Wang, X.-Z. & Ron, D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP-kinase. Science 272, 1347-1349 (1996).

Batchvarova, N., Wang, X.-Z. & Ron, D. Inhibition of adipogenesis by the stress-induced protein CHOP (GADD153). EMBO J. 14, 4654-4661 (1995).

Crozat, A. Y., Aman, P., Mandahl, N. & Ron, D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma with t(12;16)(q13;p11). Nature 363, 640-644 (1993). Download pdf

Reviews and Commentaries

Ron D and Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 8:519-529. (Download PDF)

Ron D. and Harding H.P. 2007. eIF2a phosphorylation in cellular stress-responses and disease.  In: Hershey JWB, Matthews MB, Sonenberg N, Eds. Translational Control in Biology and Medicine. Pages 345-368 (Chapter 13).  Cold Spring Harbor Press. (Download PDF)

Ron D. 2006. Stressed cells cope with protein overload. [perspectives article] Science 313:52-53.

Ron D and Hinnebusch A. 2006. Targeting translation in hypoxic tumors. [review article] ACS Chemical Biology 1:145-148

Ron D and Oyadomari S. Lipid phase perturbations and the unfolded protein response. [review article] Dev Cell 7:287-8 (2004).

Ron D and Hampton R. Membrane biogenesis and the unfolded protein response. [review article] J Cell Biol 167:23-25 (2004). (download pdf).

Ron, D. Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse [commentary] J Clin. Invest. 109: 443-445 (2002). (download pdf)

Yoneda, T., Urano, F. and Ron, D. Transmission of proteotoxicity across cellular compartments[commentary] Genes Dev 16: 1307-1313 (2002). (download pdf)

Harding, H.P., Calfon, M., Urano, F., Novoa, I. and Ron, D. Transcriptional and translational control in the mammalian unfolded protein response.[review article] Annu Rev Cell Dev Biol. 18: 575-599 (2002). (acces here)

Harding, H.P. and Ron, D. 2002. Endoplasmic reticulum stress and the development of diabetes: a review. [review article] Diabetes. 51 Suppl 3:S455-461.

Ron, D. Translational control in the endoplasmic reticulum stress response[review article] J Clin Invest. 110: 1383-1388 (2002). (download pdf)

Ron, D. Hyperhomocysteinemia and function of the endoplasmic reticulum [commentary] J Clin. Invest. 107: 1221-1222 (2001). (download pdf)

Harding H.P., Novoa I., Bertolotti A., Zeng H., Zhang A., Urano F., Jousse C., and Ron D. Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.[review article] in: Cold Spring Harbor Symposia on Quantitative Biology: 61499-508 (2001). (download pdf)

Ron D. and Harding H. PERK and translational control by stress in the endoplasmic reticulum.[review article] in: Translational Control (ed. J. Hershey, M. Mathews, and N. Sonenberg), pp. 547-560. Cold Spring Harbor Press, Cold Spring Harbor (2000). (download pdf)

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