Contents of this page:
Pathobiology Program
Course Schedule Overview
Pathobiology Faculty and Research Interests
Fall 2006 Schedule
Seminar Speakers: Grand Rounds and Pathology Seminar
Pathobiology Curriculum: Course Syllabi
Introduction to Tissues and Organ Systems
Introduction to Histopathology
Advanced Tissues and Organ Systems (provisional syllabus)
Pathobiology of Disease (provisional syllabus)
Model Organisms in Pathobiology Research (provisional syllabus)
Overview
of Program Schedule
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Fall |
Credits |
Spring |
Credits |
Summer |
Credits |
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Pre-matriculation |
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Optional: Research Lab or Clinical Rotation |
1 |
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First
Year |
Intro to Tissue and Organ Systems [Lecture/Discussion] |
4 |
Pathobiology of Disease I [Seminar Course] |
2 |
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Intro to Histopathology [Lab] |
2 |
Advanced Histopathology and Immunology [Lecture/Lab] |
4 |
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Foundations I |
6 |
Foundations II |
6 |
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Lab Rotation |
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Lab Rotation |
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Research Lab or Clinical Rotation |
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Second
Year |
Model Organisms [Lecture/Discussion] |
4 |
Pathobiology of Disease II [Seminar Course] |
4 |
Qualifying Exam |
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Elective (Genetics Recommended) |
4 |
Molecular Oncology |
4 |
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Research |
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Research |
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Research |
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Third
Year and Beyond |
Seminars in Pathobiology (see below) |
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Seminars in Pathobiology (see Below) |
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Research in Pathobiology |
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Research in Pathobiology |
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Required Seminars: Weekly Grand Rounds in Pathology Weekly Work in Progress Seminar Monthly Pathology Research Seminar |
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Required Seminars: Weekly Grand Rounds in Pathology Weekly Work in Progress Seminar Monthly Pathology Research Seminar |
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Pathobiology
of Disease Program Faculty
Clinical Faculty
|
Laura
Barisoni, M.D. |
Renal
pathology |
|
Ross
Basch, M.D. |
Developmental
hematology and immunology |
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Joan
Cangiarella, M.D. |
Breast
pathology and cytopathology |
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Hearn
J. Cho, M.D., Ph.D. |
Multiple
myeloma |
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Sandra
Demaria, M.D. |
Immunological
response to breast cancer |
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Alba
Greco, M.D. |
Pediatric
pathology |
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Tim
Hilbert, M.D., Ph.D. |
Blood
bank |
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Sherif
Ibrahim, M.D., Ph.D. |
Hematopathology |
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Jonathan
Melamed, M.D. |
Uropathology,
prostate cancer |
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Daisuke
Nonaka, M.D. |
Head
& neck, thoracic pathology |
|
Baljit
Singh, M.D. |
Breast
pathology |
|
George
Teebor, M.D., Ph.D. |
Molecular
genetics and enzymology of DNA excision repair |
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Phil
Tierno, Ph.D. |
Microbiology |
|
David
Zagzag, M.D., Ph.D. |
Mechanisms
of cerebral vasculogenesis and angiogenesis |
Research Faculty
|
Nina Bhardwaj, M.D., Ph.D. |
Immunobiology
of Antigen Presenting Cells; Cancer Vaccine Development |
|
Michael Dustin, Ph.D. |
T
cell activation, migration and adhesion. Formation of the immunological
synapse |
|
Iannis Aifantis, Ph.D. |
T
cell developmental biology and leukemogenesis |
|
Adrian Erlebacher, M.D.,
Ph.D. |
Mechanisms
underlying immune-privilege status of the fetus |
|
Joel Ernst, M.D. |
Host-pathogen
interactions in tuberculosis and other infectious diseases |
|
Eva Hernando, Ph.D. |
Cell-cycle
defects at the origin of the neoplastic transformation |
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Juan Lafaille, Ph.D. |
Pathogenesis
of autoimmune and allergic diseases |
|
David Levy, Ph.D. |
Cytokine
signaling in innate immunity to viral infections; Jak-Stat signaling in
cancer |
|
Cindy Loomis, M.D., Ph.D. |
Developmental
mechanisms in embryonic patterning and bone/skin morphogenesis |
|
John Munger, M.D. |
Transforming
growth factor-beta activation during development, wound healing, scarring
fibrosis and cancer progression |
|
Dan Meruelo, Ph.D. |
Genetic
Predispositions to Tumorigenesis and gene therapy of cancer |
|
Michele Pagano, M.D. |
Regulation
of the mammalian cell cycle and its deregulation in cancer |
|
Angel Pellicer, M.D., Ph.D. |
Molecular
alterations in tumor formation |
|
Jayne Raper, Ph.D. |
Function
of African trypanosome lytic factors as novel mediators of human innate
immunity |
|
David Roth, M.D., Ph.D. |
Mechanisms
of antigen receptor gene rearrangement, maintenance of genomic stability, and
lymphomagenesis |
|
Jane Skok, Ph.D. |
Nuclear
organization of immunoglobulin genes |
|
Ed Skolnik, M.D. |
Insulin-dependent
signal transduction pathways regulating cell growth and tumorigenesis |
|
Thomas Wisniewski, M.D. |
Processes
of normal aging, dementia, and memory disorders |
|
David Zagzag, M.D., Ph.D. |
Mechanisms
of cerebral vasculogenesis and angiogenesis |
Pathobiology of
Disease Program Fall 2006 Schedule
Orientation:
8/21 9:45 am, Presentation of new Pathobiology program by Dr. David Roth, Chairman of Pathology.
8/21 10:00 am, Meet Graduate Advisors
Pathobiology Graduate Advisor: Dr. Cindy Loomis, Assistant Professor, Departments of Pathology, Dermatology and Cell Biology.
Registration:
8/23 2:00 pm Ð 3:00 pm, registration and advisement; Meet with Dr. Cindy Loomis, Graduate Advisor
Pathobiology Open House:
8/31 5:00 pm , Pathology Conference Room, MSB 588.
Courses, Fall 2006:
Introduction to Tissues and Organ Systems
[Lecture/Discussion course]
9/11 Course begins
Monday and Wednesday, 10:30 am-12 pm, except where otherwise indicated.
Pathology Conference Room, MSB 588.
Course Directors: Drs. Cindy Loomis and Jonathan Melamed
9/15 Course begins
Friday, unless otherwise indicated. Time TBA.
Research Histopathology Core lab MSB Rm 504 or Clinical Pathology, Tisch Rm 461
Course Directors: Drs. Jonathan Melamed and Cindy Loomis
Foundations I
[Lecture/Discussion course]
8/28 Course begins
Variable days for first 6 weeks, 9 am-10 am unless otherwise indicated.
Tuesday and Thursday, 9 am-10:30 am; Friday, 9am-10:30am or 10:30am-12 pm
Course Directors: Drs. Jim Borowiec & Angus Wilson
Seminar series, Fall
2006:
Pathology Grand Rounds: Mondays 1:30-2:30 pm, 3rd Floor Jacob Bleibtreu Seminar Room, Skirball Institute.
This seminar series focuses on current topics in the area of Clinical Pathology.
Dr. Laura Barisoni directs the series.
Pathology Research Seminar series: 2nd Tuesday of each month, 3:00 pm-4:00 pm, Skirball 3rd floor, Seminar Room.
This series focuses on molecular and cellular mechanisms important in the pathobiology of disease. Dr. Sandra Demaria directs this series.
Work-in-Progress series: Wednesdays 12pm -1:00 pm, Pathology Conference room, MSB 588
Each week a graduate student or post-doc from one of the three Department of Pathology training programs presents his/her recent work. The focus of this weekly series alternates between Molecular Oncology and Immunology; and students in the Pathobiology Program choose to go to one or the other sets or to both. First year students will be expected to attend but not to present work. Dr. Angel Pellicer and Dr. David Levy organize this series.
Other seminars of
interest:
NYU Honors Lectures: Mondays, 4:00 pm-5:00 pm, Schwartz Lecture Hall, Classroom F.
Immunology Club: Thursdays, 12:00 pm-1:00 pm, 3rd Floor Jacob Bleibtreu Auditorium, Skirball Institute.
Cancer Institute Seminar Series: Wednesdays, 4:30 pm-5:30 pm, 3rd Floor Jacob Bleibtreu Auditorium, Skirball Institute.
Seminar Speakers: Pathology Grand Rounds 2005 Ð 2006*
|
September 12, 2005 |
"Thymoma - Classification and Future
Trends" Cesar Moran MD Anderson Cancer Center |
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December 5, 2005 |
"Juvenile Polyposis" Franz Fogt, M.D., Ph.D, MRCPATH, MBA University of Pennsylvania |
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September 19, 2005 |
"Pathology in the Study of Emerging Infectious
Diseases" Jeannette Guarner, M.D. Center for Disease
Control and Prevention |
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December 12, 2005 |
"Forerunner Genes: A Novel Paradigm for Cancer
Development" Bogdan Czerniak, M.D., Ph.D. M.D. Anderson Cancer Center |
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September 26, 2005 |
"Nuclear Restructuring by an Oncogenic Tyrosine
Kinase". Andrew Fischer, M.D. University of Massachusetts |
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January 30, 2006 |
"New Insights in Barret's Esophagus" Haidrum Rotterdam Columbia University |
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October 17, 2005 |
"Amyloid in Surgical Pathology: Where Were We
and Where Are We Heading?" Maria Picken M.D. Ph.D. Loyola University Health System |
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March 13, 2006 |
"How Molecular Monitoring Strategies Influence
Pathology Practice in the Era of Targeted Therapy" Dan Jones, M.D., Ph.D. University of Texas MD Anderson Cancer Center |
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October 24, 2005 |
"Focal Segmental Glomerulosclerosis" Jeffrey Kopp National Institute of Health |
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April 10, 2006 |
"DNA Fingerprinting vs. DNA From
Fingerprints" Theresa Caragine, Ph.D. Office of the Chief Medical Examiner |
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October 31, 2005 |
"Engineering the Sporadic Activation of
Oncogenes in Vivo, by Somatic Hypermutation: Mouse Models for Lymphomas and
Multiple Myeloma" Davide Robbiani The Rockefeller University |
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April 17, 2006 |
"How Exology and Evolutionary Theory Illuminate
the Natural History of Tumors" Jose Costa, M.D. Yale University School of Medicine |
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November 7, 2005 |
"The Importance of Cytogenetics in Tumor
Pathology" Paola Dal Cin, Ph.D. Brigham & Women's Hospital |
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April 24, 2005 |
"Borderline Tumors of the Ovary: Beyond the
Border of Borderline" Robert Kurman, M.D. The Johns Hopkins University School of Medicine |
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* Partial Listing |
||||
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November 14, 2005 |
"Idiopathic Interstitial Pneumonias: Current Concepts" William D Travis Memorial Sloan-Kettering Cancer Center |
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May 15, 2006 |
"Osteosarcoma: PerspectivesÉ" Kevin Raymond, M.D. University of Texas
M.D. Anderson Cancer Center |
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November 21, 2005 |
"Patient Safety in Anatomic Pathology" Stephen Raab, M.D., Ph.D. University of Pittsburgh Medical Center |
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May 22, 2006 |
ÒDiagnostic Problems in Liver Transplant Pathology Jay Lefkowitch, M.D. Columbia University |
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November 28, 2005 |
"Influenza Pathophysiology: From 1918 to the Present" Jeffery K. Taubenberger, M.D., Ph.D. Armed Forces Institute of Pathology |
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June 5, 2006 |
"Selected topics in Thyroid Pathology---My
experience with Virginia A. LiVolsi, M.D." Changcheng Zhu, M.D. University of Pennsylvania |
|
September 20, 2005 |
Regulation
of the G1-S phase transition by Notch Signaling: an alternative mechanism for
modulating cell fate decisionsÓ
Nadia Carlesso, M.D., Ph.D. Mass General, Harvard Medical School |
|
October 11, 2006 |
ÒDynamic
imaging of the immune response in vivo- histopathology in 5 dimensionsÓ
Michael Dustin, Ph.D. Skirball Institute, NYU |
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November 8, 2005 |
ÒRegulating
Cyclin Accumulation by the Emi1 and Evi5 Stabilizing FactorsÓ
Peter K. Jackson, Ph.D. Stanford University School of Medicine |
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December 13, 2005 |
ÒUbiquitin
ligases: deregulated cell cycle control and proteolysis in (guess what?)
cancerÓ
Michel Pagano, M.D. New York University School of Medicine |
|
January 17, 2006 |
ÒTelomeres
require special mechanisms for segregation
at mitosisÓ Susan Smith, Ph.D.
Skirball
Institute Program of Molecular Pathogenesis, NYU
|
|
February 28, 2006 |
ÒIndication
& Testing of a Gene Expression Signature for Invasion Metastasis in
Mammary TumorÓ
John
Condeelis, Ph.D.
Albert Einstein School of Medicine |
|
March 7, 2006 |
ÒA
Loss-of-function RNA interference screen for molecular targets in cancerÓ
Lou
Staudt, M.D., Ph.D.
National Cancer Institute, Bethesda, Maryland |
|
March 28, 2006 |
ÒDeveloping
an Integrated TransMed InfrastructureÓ
Craig
Webb, Ph.D.
Van Andel Research Institute, Grand Rapids, Michigan |
|
May 9, 2006 |
ÒRegulatory T cells in the control of allergic and
autoimmune diseasesÓ
Juan
Lafaille, Ph.D.
Skirball Institute Molecular Pathogenesis, NYU |
|
May 16, 2006 |
ÒMouse models to investigate cyclin-dependent
kinases (Cdks)Ó Philip
Kaldis, Ph.D.
National Cancer Institute, Mouse Cancer Genetics
Program |
Course
Descriptions
Introduction to Tissues and Organ Systems
Course director: Cynthia Loomis, M.D., Ph.D.
Lecture and Discussion course
Time: Fall Semester, starting Ô06
Monday 10:30 am-12:00 pm
Wednesday 10:30 am Ð 12:00 pm
(Unless otherwise noted below)
Location: Pathology Conference Room, MSB 588
Credits: 4 (40 hours)
Overview: This introductory course, specifically designed for Pathobiology graduate students, will cover selected basic concepts of tissue organization, anatomy, physiology, and pathology that will allow biomedical research scientists to pursue disease-oriented research topics and more effectively employ animal models of disease. In particular, this overview will familiarize students with basic principles of how mammalian organisms function physiologically in normal and diseased states, and introduce selected concepts used in clinical medicine. The first half of the course will provide an overview of normal anatomy and tissue histology, and will define general pathological processes that alter the normal or healthy state. The second half of the course will explore in more detail the gross and histopathological alterations that occur during clinical disease, and it will be organized by major organ systems.
This course will be directed by Cynthia Loomis, M.D., Ph.D. and Jonathan Melamed, M.D. Bi-weekly lectures will be given by a mixture of clinical, translational, and basic science faculty. In addition, a portion of this course will also consist of directed readings in pathogenesis and related literature (e.g., cancer biomarkers), with group discussions of the reading material led by students and monitored by faculty with expertise in each area. The topics covered in the lectures and discussions will be closely coordinated with the Introduction to Histopathology laboratory course, and many faculty will be involved in both courses to ensure continuity.
We will begin with an overview of general disease processes and mechanisms, and then focus on these processes as manifested in specific organ systems. The course will follow the general chapter outline of the Robbins pathology text, with the relevant chapter titles provided below for each week. Carefully selected reading assignments will be provided; we do not expect the students to read the entire text. In some cases, current research papers applicable to the weeksÕ topics will be given out and then discussed by the group at the end of the relevant lecture.
Required textbook:
Robbins and Cotran,
Pathologic Basis of Disease; 7th
Ed. Kumar, Abbas, Fausto, Elsevier Saunders, 2005.
Optional textbooks:
Basic Histology: text and
atlas. 11th Ed. , L.C. Junqueira, J. Carneiro.
McGraw-Hill, 2005.
GrantÕs Atlas of Anatomy, 11th Ed. A.M.R. Agur, A.F. Dalley.
Lippincott, Williams & Wilkins. 2005
Introduction to Tissues
and Organ Systems Outline: Lectures and Discussions
Monday
9/11/06 Overview
of Course Roth
Wednesday 9/13/06 Anatomical Relationships I Loomis
Monday 9/18/06 Basic Org. of Simple Organs I Loomis
Wednesday 9/20/06 Basic Org. of Simple Organs I Loomis
Monday 9/25/06 Cell Death and Injury; Apoptosis, Necrosis Loomis
Wednesday 9/27/06 Tissue Repair and Renewal Loomis
Monday 10/02/06 Yom Kippur, NO LECTURE
Wednesday 10/04/06 BASIC Immunology Roth
Monday 10/09/06 Columbus Day, NO LECTURE
Wednesday 10/11/06 Inflammation Roth
Monday 10/16/06 Lab session, NO LECTURE
Wednesday 10/18/06 Neoplasia Roth
Monday 10/23/06 Exogenous Causes of Disease Loomis
Wednesday 10/25/06 Endogenous Causes of Disease Loomis
Monday 10/30/06 Midterm
Wednesday 11/01/06 Surface tissues: skin, cornea Loomis
Monday 11/06/06 Gastrointestinal, Basic Melamed
Wednesday 11/08/06 Gastrointestinal, pathobiology Petrovic
Monday 11/13/06 Respiratory, Basic Melamed
Wednesday 11/15/06 Respiratory pathobiology Nonaka
Monday 11/20/06 Breast