The goals of this course are to provide students with an introduction to protein structure and to demonstrate how knowledge of the three-dimensional structures of proteins affords an in-depth understanding of biological processes. A primer on structure determination by x-ray crystallography, electron microscopy and NMR spectroscopy will also be given.
4 credit hours.
Classes meet Mon., Wed. and Fri., 10:30 - 12:00.
Course starts on Mon., Sept. 10th.
Lectures (Mon. and Wed.) will be held in the Skirball 3rd floor
seminar room, and the discussion session (Fri.) will be held in the Skirball
3rd floor conference room.
Recommended text: "Introduction to Protein Structure" by Branden
and Tooze, available for purchase at the NYU Medical Bookstore and Amazon.com,
and on reserve in the library.
Course director: Steve Hubbard - Skirball 3rd floor, Lab 4; 263-8938;
hubbard@saturn.med.nyu.edu
Final paper sign-up
Discussion session sign-up
Useful Links
Protein Data Bank
Swiss-PdbViewer
PyMol (program download)
PyMol (users manual)
Take the new and improved
stereo test!
Kinemage files
Course Schedule
Week 1 (9/10 - 9/14)
Principles of protein structure /
Introduction to x-ray crystallography and electron microscopy
Steve Hubbard / Da-Neng Wang
Week 2 (9/17 - 9/21)
Histone modifications and regulation of gene expression
Rui-Ming Xu
Week 3 (9/24 - 9/28)
Molecular machines - myosin, kinesin, ion pumps
David Stokes
Week 4 (10/1 - 10/5)
Enzyme structure and mechanism
Xiang-Peng Kong
Week 5 (10/8 - 10/12)
Protein-nucleic acid recognition
Joel Belasco
Week 6 (10/15 - 10/19)
Membrane proteins
Da-Neng Wang
Week 7 (10/22 - 10/26)
No class - Skirball retreat
Week 8 (10/29 - 11/2)
Ligand-receptor recognition
Moosa Mohammadi
Week 9 (11/5 - 11/9)
Protein-protein interactions in signal transduction
Steve Hubbard
Week 10 (11/12 - 11/16)
Chaperone-assisted protein folding and protein degradation
David Ron
Week 11 (11/19 - 11/23); Mon. only (Thanksgiving week)
In-class exam
Week 12 (11/26 - 11/30)
Antigen-T cell recognition
Michelle Krogsgaard
Week 13 (12/3 - 12/7)
Analysis of proteins by mass spectrometry
Tom Neubert
NMR methods for structure determination
Alexej Jerschow
Computational approaches in structural biology
Richard Bonneau