The goals of this course are to provide students with an introduction to protein structure and to demonstrate how knowledge of the three-dimensional structures of proteins affords an in-depth understanding of biological processes. A primer on structure determination by x-ray crystallography, electron microscopy and NMR spectroscopy will also be given.
4 credit hours.
Classes meet Mon., Wed. and Fri., 10:30 - 12:00.
Course starts on Mon., Sept. 13th.
Lectures (Mon. and Wed.) will be held in the Skirball 3rd floor
seminar room, and the discussion session (Fri.) will be held in the Skirball
3rd floor conference room.
Recommended text: "Introduction to Protein Structure" by Branden
and Tooze, available at the NYU Medical Bookstore and in the library.
Course director: Steve Hubbard - Skirball 3rd floor, Lab 4; 263-8938;
hubbard@saturn.med.nyu.edu
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Course Schedule
Week 1 (9/13 - 9/17)
Principles of protein structure and folding
Steve Hubbard / Neville Kallenbach
Week 2 (9/20 - 9/24)
Introduction to x-ray crystallography and
electron microscopy
Steve Hubbard / Da-Neng Wang / David Stokes
Week 3 (9/27 - 10/1)
Enzyme structure and mechanism
Xiangpeng Kong
Week 4 (10/4 - 10/8)
Molecular machines - myosin, kinesin, ion pumps
David Stokes
Week 5 (10/11 - 10/15)
Membrane proteins
Da-Neng Wang
Week 6 (10/18 - 10/22)
Ligand-receptor recognition
Moosa Mohammadi
Week 7 (10/25 - 10/29)
Protein-protein interactions in signal transduction
Steve Hubbard
Week 8 (11/1 - 11/5)
Chaperone-assisted protein folding and protein degradation
David Ron
Week 9 (11/8 - 11/12) no class (Skirball retreat)
Work on final papers
Week 10 (11/15 - 11/19)
Protein-nucleic acid recognition
Joel Belasco
Week 11 (11/22 - 11/26) Mon. only (Thanksgiving week)
Mid-term exam
Week 12 (11/29 - 12/3)
NMR methods for structure determination
Alexej Jerschow
Analysis of proteins by mass spectrometry
Tom Neubert
Computational approaches in structural biology
Yingkai Zhang
Week 13 (12/6- 12/10)
X-ray crystallography lab
Steve Hubbard / Xiangpeng Kong
Mass spectrometry lab
Tom Neubert
Electron microscopy lab
David Stokes / Da-Neng Wang
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