Belasco Laboratory
Home Joel G. Belasco Lab Personnel Publications Contact Us
Publications

  • MicroRNAs direct rapid deadenylation of mRNA.
      • Wu L, Fan J, Belasco JG
      Proc. Natl. Acad. Sci. USA 103: 4034-4039 (2006)
  • Lost in translation: the influence of ribosomes on bacterial mRNA decay.
      • Deana A, Belasco JG
      Genes Dev. 19: 2526-2533 (2005)
  • MicroRNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells.
      • Wu L, Belasco JG
      Mol. Cell. Biol. 25: 9198-9208 (2005)
  • Catalytic activation of multimeric RNase E and RNase G by 5'-monophosphorylated RNA.
      • Jiang X, Belasco JG
      Proc. Natl. Acad. Sci. USA 101: 9211-9216 (2004)
  • The function of RNase G in Escherichia coli is constrained by its amino and carboxyl termini.
      • Deana A, Belasco JG
      Mol. Microbiol. 51: 1205-1217 (2004)
  • Two distinct regions on the surface of an RNA-binding domain are crucial for RNase E function.
      • Diwa AA, Jiang X, Schapira M, Belasco JG
      Mol. Microbiol.46(4): 959-969 (2002), Erratum in Mol. Microbiol. 47(4): 1183 (2003)
  • Critical features of a conserved RNA stem-loop important for feedback regulation of RNase E synthesis
      • Diwa AA, Belasco JG
      J. Biol. Chem.277: 20415-20422 (2002)
  • Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells
      • Feldbrugge M, Aritzi P, Sullivan ML, Zamore PD, Belasco JG, Green PJ
      Plant Mol. Biol.49: 215-223 (2002)
  • Consequences of RNase E scarity in Escherichia coli.
      • Jain C, Deana A, Belasco JG
      Mol. Microbiol. 43: 1053-1064 (2002)
  • T7 phage display: a novel genetic selection system for cloing RNA-binding proteins from cDNA libraries.
      • Danner S, Belasco JG
      Proc.Natl.Acad.Sci.USA 98: 12954-12959 (2001)
  • Structural model for the cooperative assembly of HIV-1 Rev multimers on the RRE as deducted from analysis of assembly-defective mutants.
      • Jain C, Belasco JG
      Mol. Cell 7: 603-614 (2001)
  • An evolutionarily conserved RNA stem-loop functions as a sensor that directs feedback regulation of RNase E gene expression.
      • Diwa A, Bricker AL, Jain C, Belasco JG
      Genes Dev. 14:1249-1260 (2000)
  • Regions of RNase E important for 5'-end-dependent RNA cleavage and autoregulated synthesis.
      • Jiang X, Diwa A, Belasco JG
      J. Bacteriol. 182: 2468-2475 (2000)
  • Rapid genetic analysis of RNA-protein interactions by translational repression in E.coli
      • Jain C, Belasco JG
      Methods Enzymol.3118: 309-332 (2000)
  • Importance of a 5' stem-loop for longevity of papA mRNA in Escherichia coli.
      • Bricker AL, Belasco JG
      J. Bacteriol.181: 3587-90 (1999)
  • Target discrimination by RNA-binding proteins: role of the ancillary protein U2A' and a critical leucine residue in differentiating the RNA-binding specificity of spliceosomal proteins U1A and U2B".
      • Rimmele ME, Belasco JG
      RNA4: 1386-1396 (1998)
  • mRNA stabilization by the ompA 5' untranslated region: two protective elements hinder distinct pathways for mRNA degradation.
      • Arnold TE, Yu J, Belasco JG
      RNA4: 319-330 (1998)
  • RNA-binding proteins tamed
      • Laird-Offringa IA, Belasco, JG
      Nature Struct. Biol.5: 665-668 (1998)
  • RNA recognition by the joint action of two nucleolin RNA-binding domains: genetic analysis and structural modeling.
      • Bouvet P, Jain C, Belasco JG, Amalric F, Erard M
      EMBO J.16: 5235-5246 (1997)
  • A rapid genetic method for the study of RNA binding proteins.
      • Jain C, Belasco JG
      In Richter JD, ed., mRNA Formation and Function.Academic Press, 263-284 (1997)
  • A structural model for the HIV-1 Rev-RRE complex deduced from altered-specificity rev variants isolated by a rapid genetic strategy.
      • Jain C, Belasco JG
      Cell87: 115-125. (1996)
  • Translation of the adhE transcript to produce ethanol dehydrogenase requires RNase III cleavage in Escherichia coli.
      • Aristarkhov A, Mikulskis A, Belasco JG, Lin ECC
      J. Bacteriol.178: 4327-4332. (1996)
  • In vitro genetic analysis of RNA-binding proteins using phage display libraries.
      • Laird-Offringa IA, Belasco JG
      Methods Enzymol267: 149-168
  • Analysis of RNA-binding proteins by in vitro genetic selection: identification of an amino acid residue important for locking U1A onto its RNA target.
      • Laird-Offringa IA, Belasco JG
      Proc. Natl. Acad. Sci. USA 92: 11859-11863 (1995)
  • The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation.
      • Zubiaga AM, Belasco JG, Greenberg ME
      Mol. Cell. Biol.15: 2219-2230 (1995)
  • Autoregulation of RNase E synthesis in Escherichia coli.
      • Jain C, Belasco JG
      Nucleic Acids Symp. Ser.33: 85-88 (1995)
  • RNase E autoregulates its synthesis by controlling the degradation rate of its own mRNA in Escherichia coli: unusual sensitivity of the rne transcript to RNase E activity.
      • Jain C, Belasco JG
      Genes Dev9: 84-96 (1995)
  • The ompA 5' untranslated region impedes a major pathway for mRNA degradation in Escherichia coli.
      • Hansen MJ, Chen LH, Fejzo ML, Belasco JG
      Mol Microbiol.9: 84-96 (1995)
  • Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.
      • Schiavi SC, Wellington CL, Shyu AB, Chen CY, Greenberg ME, Belasco JG
      J. Biol. Chem.269: 3441-3448 (1994)
  • The destabilizing elements in the coding region of c-fos mRNA are recognized as RNA.
      • Wellington CL, Greenberg ME, Belasco JG
      Mol. Cell. Biol.5034-5042 (1993)
  • Regulation of proto-oncogene mRNA stability.
      • Schiavi SC, Belasco JG, Greenberg ME
      Biochem. Biophys. Acta1114 : 95-106 (1992)
  • Control of RNase E-mediated RNA degradation by 5'-terminal base pairing in E. coli.
      • Bouvet P, Belasco JG
      Nature360:488-491 (1992)
  • A 5'-terminal stem-loop structure can stabilize mRNA in Escherichia coli.
      • Emory SA, Bouvet P, Belasco JG
      Genes Dev.6: 135-148 (1992)
  • Structure and function of a bacterial mRNA stabilizer: analysis of the 5' untranslated region of ompA mRNA.
      • Chen LH, Emory SA, Bricker AL, Bouvet P, Belasco JG
      J. Bacteriol.173: 4758-4586 (1991)
  • Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.
      • Shyu AB, Belasco JG, Greenberg ME
      Genes Dev.172: 4578-4586 (1991)
  • Degradation of pufLMX mRNA in Rhodobacter capsulatus is initiated by nonrandom endonucleolytic cleavage.
      • Chen CY, Belasco JG
      J. Bacteriol.172: 4578-4586 (1990)
  • The ompA 5' untranslated RNA segment functions in Escherichia coli as a growth-rate-regulated mRNA stabilizer whose activity is unrelated to translational efficiency.
      • Emory SA, Belasco JG
      J. Bacteriol.172: 4472-4481 (1990)
  • Deadenylylation: a mechanism controlling c-fos mRNA decay.
      • Greenberg ME, Shyu AB, Belasco JG
      Enzyme44: 181-192 (1990)
  • The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.
      • Shyu AB, Greenberg ME, Belasco JG
      Genes Dev.3: 60-72 (1989)
  • Mechanism of puf mRNA degradation: the role of an intercistronic stem-loop structure.
      • Belasco JG, Chen CY
      Genes Dev.72: 109-117 (1988)
  • Mechanisms of mRNA decay in bacteria: a perspective.
      • Belasco JG, Higgins CF
      Gene72: 15-23 (1988)
  • An intercistronic stem-loop structure functions as an mRNA decay terminator necessary but insufficient for puf mRNA stability.
      • Chen CY, Beatty JT, Cohen SN, Belasco JG
      Cell52: 609-619 (1988)
  • Effect of premature termination of translation on mRNA stability depends on the site of ribosome release.
      • Nilsson G, Belasco JG, Cohen SN, von Gabain
      Proc. Natl. Acad. Sci. USA84: 4890-4894 (1987)
  • The stability of E. coli gene transcripts is dependent on determinants localized to specific mRNA segments.
      • Belasco JG, Nilsson G, von Gabain A, Cohen SN
      Cell46: 245-251 (1986)
  • Energetics of proline racemase: rates, fractionation factors, and buffer catalysis in the oversaturated region. Nature of the interconversion of the two forms of free enzyme.
      • Belasco JG, Bruice TW, Fisher LM, Albery WJ, Knowles JR
      Biochemistry25: 2564-2571 (1986)
  • Energetics of proline racemase: fractionation factors for the essential catalytic groups in the enzyme-substrate complexes.
      • Belasco JG, Bruice TW, Albery WJ, Knowles JR
      Biochemistry25: 2558-2564 (1986)
  • Energetics of proline racemase: double fractionation experiment, a test for concertedness and for transition-state dominance.
      • Belasco JG, Albery WJ, Knowles JR
      Biochemistry25: 2552-2558 (1986)
  • Energetics of proline racemase: transition-state fractionation factors for the two protons involved in the catalytic steps.
      • Fisher LM, Belasco JG, Bruice TW, Albery WJ, Knowles JR
      Biochemistry25: 2543-2551 (1986)
  • Differential expression of photosynthesis genes in R. capsulata results from segmental differences in stability within the polycistronic rxcA transcript.
      • Belasco JG, Beatty JT, Adams CW, von Gabain A, Cohen SN
      Cell40: 171-181 (1985)
  • Growth-rate dependent regulation of mRNA stability in Escherichia coli.
      • Nilsson G, Belasco JG, Cohen SN, von Gabain A
      Nature312: 75-77 (1984)
  • Decay of mRNA in Escherichia coli: investigation of the fate of specific segments of transcripts.
      • von Gabain A, Belasco JG, Schottel JL, Chang AC, Cohen SN
      Proc. Natl. Acad. Sci. USA 80: 653-657 (1983)
  • Polarization of substrate carbonyl groups by yeast aldolase: investigation by Fourier transform infrared spectroscopy.
      • Belasco JG, Knowles JR
      Biochemistry22: 122-129 (1983)
  • Beta-lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin.
      • Fisher J, Belasco JG, Khosla S, Knowles JR
      Biochemistry19: 2859-2901 (1980)
  • Beta-lactamase inactivation by mechanism-based reagents.
      • Fisher J, Belasco JG, Charnas RL, Khosla S, Knowles JR
      Philos. Trans. R. Soc. Lond. B. Biol. Sci.289: 309-319 (1980)
  • Direct observation of substrate distortion by triosephosphate isomerase using Fourier transform infrared spectroscopy.
      • Belasco JG, Knowles JR
      Biochemistry19: 472-477 (1980)
  • Critical ionization states in the reaction catalyzed by triosephosphate isomerase.
      • Belasco JG, Herlihy JM, Knowles JR
      Biochemistry17: 2971-2978 (1978)
    Last Updated: 28-Mar-2003, Daphne Gilles