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Selected Publications
Crystal structure of the Frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK
Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14
The juxtamembrane region of EGFR takes center stage
Structure and mechanism of the insulin receptor tyrosine kinase
Structures of serine/threonine and tyrosine kinases
Lrp4 is a receptor for Agrin and forms a complex with MuSK
Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2
How IRE1 responds to ER stress
Crystal structure of the human laminin receptor precursor
Receptor tyrosine kinases: mechanisms of activation and signaling
Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK
Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3
Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS
EGF receptor activation: push comes to shove
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14
EGF receptor inhibition: attacks on multiple fronts
Structural characterization of a novel Cbl phosphotyrosine-recognition motif in the APS family of adapter proteins
Juxtamembrane autoinhibition in receptor tyrosine kinases
Oncogenic mutations in B-Raf: some losses yield gains
Structural basis for recruitment of the adaptor protein APS to the
activated insulin receptor
Structural and biochemical evidence for an autoinhibitory role for
tyrosine 984 in the juxtamembrane region of the insulin receptor
Structural basis for dimerization of the Grb10 SH2 domain: implications
for ligand specificity
Protein tyrosine kinases: autoregulation and small-molecule inhibition
Crystal structure of the MuSK tyrosine kinase: insights into receptor
autoregulation
Autoinhibitory mechanisms in receptor tyrosine kinases
Structure and autoregulation of the insulin-like growth factor 1
receptor kinase
The BPS domain of Grb10 inhibits the catalytic activity of the insulin
and IGF1 receptors
Crystallographic and solution studies of an activation loop mutant
of the insulin receptor tyrosine kinase: insights into kinase mechanism
Mechanism-based design of a protein kinase inhibitor
Probing the catalytic mechanism of the insulin receptor kinase with
a tetrafluorotyrosine-containing peptide substrate
Protein tyrosine kinase structure and function
Structural basis for FGF receptor dimerization and activation
Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated
protein beta
Structural analysis of receptor tyrosine kinases
Src autoinhibition: let us count the ways
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor
tyrosine kinase domain
Autoregulatory mechanisms in protein-tyrosine kinases
Crystal structure of the activated insulin receptor tyrosine kinase
in complex with peptide substrate and ATP analog
Structures of the tyrosine kinase domain of fibroblast growth factor
receptor in complex with inhibitors
Structure of the FGF receptor tyrosine kinase domain reveals a novel
autoinhibitory mechanism
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