Structural Biology of Membrane Proteins

Our laboratory aims to understand the molecular mechanisms of membrane transport by structural biology approaches. We recently determined the 3.3 Å structure of the glycerol-3-phosphate transporter from the E. coli inner membrane, a member of the major facilitator superfamily (>5,000 members). The result was published in Science (2003).

MOVIE1 - GlpT structure
MOVIE2 - Proposed GlpT conformational changes